Mechanisms of Radiation-induced toxicity

The majority of patients with brain metastasis are treated with radiation (stereotactic radiosurgery-SRS) as part of their standard of care. However, radiation induced toxicity (necrosis and edema) has emerged as a critical side effect, particularly for patients receiving certain combinations of targeted therapies for their tumors. We have identified dysregulation of water-channels APQ4 in astrocytes, as one mediator of cytotoxic edema in the brain following SRS for Her2+ brain metastasis treated in combination with Trastuzumab emtansine (PMCDI: PMC6751332).

©2019 American Association for Cancer Research

Funded by DoD postdoctoral breakthrough award (to MJC)